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Current Clinical Trials

REGN7508 versus ASA for Venous Thromboprophylaxis After Total Knee Arthroplasty
  1. Erik Schnaser, MD
    Erik Schnaser, MD
  2. for people 18 Years and up (full criteria)
  3. Rancho Mirage, CA
  4. study started February 2026
  5. Erik Schnaser, MD
  6. Accepting new patients

Description

Summary

This study is researching an experimental drug called REGN7508 versus Acetylsalicylic Acid (ASA) (each called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: -What side effects may happen from taking the study drug -How much study drug is in the blood at different times -Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Official Title

A Phase 3, Multicenter, Double-Blinded, Randomized Study to Evaluate REGN7508, a Factor XI Monoclonal Antibody, Versus Acetylsalicylic Acid for Prophylaxis of Symptomatic Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-ASPEN)

Keywords

Prophylaxis of Symptomatic Venous Thromboembolism (VTE)

Eligibility

for people 18 Years and up
Key Inclusion Criteria:1. Is undergoing a primary elective unilateral TKA2. Is in good health based on laboratory safety testing as described in the protocolKey Exclusion Criteria:1. Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study participation2. History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, exces... more
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Key Inclusion Criteria:1. Is undergoing a primary elective unilateral TKA2. Is in good health based on laboratory safety testing as described in the protocolKey Exclusion Criteria:1. Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study participation2. History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis (eg, hemophilia A or B, von Willebrand’s Factor deficiency)3. History of thromboembolic disease or thrombophilia4. History of platelet dysfunction5. Has received or plans to receive preoperative enoxaparin on the day prior to TKA surgeryNote: Other protocol-defined Inclusion/ Exclusion criteria apply

Lead Scientists at Eisenhower Health

Erik Schnaser, MD
Erik Schnaser, MD. is a fellowship-trained hip and knee replacement surgeon. He specializes in adult hip and knee disorders including pre-arthritic and arthritic conditions. He has a special interest in patient-specific instrumentation, surgical navigation, robotic surgery, as well as taking care of and revising patients with failing or failed total joint replacements. His surgical skill set includes, but is not limited to total hip replacements, total knee replacements, partial knee replacement... more
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Erik Schnaser, MD. is a fellowship-trained hip and knee replacement surgeon. He specializes in adult hip and knee disorders including pre-arthritic and arthritic conditions. He has a special interest in patient-specific instrumentation, surgical navigation, robotic surgery, as well as taking care of and revising patients with failing or failed total joint replacements. His surgical skill set includes, but is not limited to total hip replacements, total knee replacements, partial knee replacements, knee arthroscopies, total hip revisions, total knee revisions, and lower extremity traumatic injuries.

“The great thing about specializing in hip and knee replacements is that these procedures truly have the ability to give patients their lives back. Few careers are this rewarding.”

Dr. Schnaser is originally from Carson City, Nevada and is the son of an orthopedic surgeon. He received his Bachelors of Science in Biochemistry at the University of Southern California and then attended medical school at the University of Nevada School of Medicine. He then completed a surgical internship and an orthopedic surgical residency at Case Western Reserve School of Medicine. Following his residency, Dr. Schnaser completed a fellowship in adult hip and knee reconstruction at the Hospital for Special Surgery in New York City.

Dr. Schnaser is particularly interested in researching clinical outcomes after hip and knee replacements. He believes that patient-specific instrumentation, navigation, and robotics have the potential to increase patient satisfaction and clinical outcomes following joint replacement surgery. He has given over 20 national and international presentations stemming from his research, has authored several peer-reviewed publications, and has written book chapters on the subject of joint replacement surgery. He was a member of the America Academy of Orthopedic Surgeon’s Research Development Committee and has spent time on Capitol Hill in order to ensure that the National Institutes of Health continues to receive research support for musculoskeletal conditions.

Publications:

To view a listing of Dr. Schnaser's publications, click here.

Clinical Study Details

  1. Accepting new patients
  2. study started February 2026
  4. NCT07213778
  5. Double-blind, Randomized Interventional,
  6. April 07, 2026

Resources

Key Contacts

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